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AstraZeneca ltd feedforward ann
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Spectroscopy:

Article Title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development
Article Snippet: Melcher et al. (2015)To apply 2 ML models to predict endpoint measures from spectroscopy online data Austria N/A Upstream E. coli Predictive Modelling 25 cultures RF; Feed-forward NN; PLSR N/A Process Variables; Mass Spec / Chromatography Cell dry mass; Product concentration missing data; multi-collinearity; time series Using neural networks as a modelling technique and random forest as a variable selection tools gives satisfactory prediction accuracy from process variables and spectroscopic data Glassey et al. (1994) To use feedforward ANN to predict biomass concentration from feed rate, batch age, batch concentration, feed initiation time, and fermentation temperature United Kingdom Astrazeneca Upstream E. coli K12 Process Optimisation 12 batches Feed-forward NN Chemotaxis algorithmInput/Control Parameter; Process Variables Biomass small data; model complexity; nonlinearity Neural networks are capable of capturing the nonlinear relationship between the fermentation input and output variables with limited a priori knowledge about the process structure (continued on next page) DigitalChemicalEngineering7(2023)100080 14 T.D.Pham et al. Table C.3 (continued).

Mass Spectrometry:

Article Title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development
Article Snippet: Melcher et al. (2015)To apply 2 ML models to predict endpoint measures from spectroscopy online data Austria N/A Upstream E. coli Predictive Modelling 25 cultures RF; Feed-forward NN; PLSR N/A Process Variables; Mass Spec / Chromatography Cell dry mass; Product concentration missing data; multi-collinearity; time series Using neural networks as a modelling technique and random forest as a variable selection tools gives satisfactory prediction accuracy from process variables and spectroscopic data Glassey et al. (1994) To use feedforward ANN to predict biomass concentration from feed rate, batch age, batch concentration, feed initiation time, and fermentation temperature United Kingdom Astrazeneca Upstream E. coli K12 Process Optimisation 12 batches Feed-forward NN Chemotaxis algorithmInput/Control Parameter; Process Variables Biomass small data; model complexity; nonlinearity Neural networks are capable of capturing the nonlinear relationship between the fermentation input and output variables with limited a priori knowledge about the process structure (continued on next page) DigitalChemicalEngineering7(2023)100080 14 T.D.Pham et al. Table C.3 (continued).

Chromatography:

Article Title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development
Article Snippet: Melcher et al. (2015)To apply 2 ML models to predict endpoint measures from spectroscopy online data Austria N/A Upstream E. coli Predictive Modelling 25 cultures RF; Feed-forward NN; PLSR N/A Process Variables; Mass Spec / Chromatography Cell dry mass; Product concentration missing data; multi-collinearity; time series Using neural networks as a modelling technique and random forest as a variable selection tools gives satisfactory prediction accuracy from process variables and spectroscopic data Glassey et al. (1994) To use feedforward ANN to predict biomass concentration from feed rate, batch age, batch concentration, feed initiation time, and fermentation temperature United Kingdom Astrazeneca Upstream E. coli K12 Process Optimisation 12 batches Feed-forward NN Chemotaxis algorithmInput/Control Parameter; Process Variables Biomass small data; model complexity; nonlinearity Neural networks are capable of capturing the nonlinear relationship between the fermentation input and output variables with limited a priori knowledge about the process structure (continued on next page) DigitalChemicalEngineering7(2023)100080 14 T.D.Pham et al. Table C.3 (continued).

Concentration Assay:

Article Title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development
Article Snippet: Melcher et al. (2015)To apply 2 ML models to predict endpoint measures from spectroscopy online data Austria N/A Upstream E. coli Predictive Modelling 25 cultures RF; Feed-forward NN; PLSR N/A Process Variables; Mass Spec / Chromatography Cell dry mass; Product concentration missing data; multi-collinearity; time series Using neural networks as a modelling technique and random forest as a variable selection tools gives satisfactory prediction accuracy from process variables and spectroscopic data Glassey et al. (1994) To use feedforward ANN to predict biomass concentration from feed rate, batch age, batch concentration, feed initiation time, and fermentation temperature United Kingdom Astrazeneca Upstream E. coli K12 Process Optimisation 12 batches Feed-forward NN Chemotaxis algorithmInput/Control Parameter; Process Variables Biomass small data; model complexity; nonlinearity Neural networks are capable of capturing the nonlinear relationship between the fermentation input and output variables with limited a priori knowledge about the process structure (continued on next page) DigitalChemicalEngineering7(2023)100080 14 T.D.Pham et al. Table C.3 (continued).

Selection:

Article Title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development
Article Snippet: Melcher et al. (2015)To apply 2 ML models to predict endpoint measures from spectroscopy online data Austria N/A Upstream E. coli Predictive Modelling 25 cultures RF; Feed-forward NN; PLSR N/A Process Variables; Mass Spec / Chromatography Cell dry mass; Product concentration missing data; multi-collinearity; time series Using neural networks as a modelling technique and random forest as a variable selection tools gives satisfactory prediction accuracy from process variables and spectroscopic data Glassey et al. (1994) To use feedforward ANN to predict biomass concentration from feed rate, batch age, batch concentration, feed initiation time, and fermentation temperature United Kingdom Astrazeneca Upstream E. coli K12 Process Optimisation 12 batches Feed-forward NN Chemotaxis algorithmInput/Control Parameter; Process Variables Biomass small data; model complexity; nonlinearity Neural networks are capable of capturing the nonlinear relationship between the fermentation input and output variables with limited a priori knowledge about the process structure (continued on next page) DigitalChemicalEngineering7(2023)100080 14 T.D.Pham et al. Table C.3 (continued).

Chemotaxis Assay:

Article Title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development
Article Snippet: Melcher et al. (2015)To apply 2 ML models to predict endpoint measures from spectroscopy online data Austria N/A Upstream E. coli Predictive Modelling 25 cultures RF; Feed-forward NN; PLSR N/A Process Variables; Mass Spec / Chromatography Cell dry mass; Product concentration missing data; multi-collinearity; time series Using neural networks as a modelling technique and random forest as a variable selection tools gives satisfactory prediction accuracy from process variables and spectroscopic data Glassey et al. (1994) To use feedforward ANN to predict biomass concentration from feed rate, batch age, batch concentration, feed initiation time, and fermentation temperature United Kingdom Astrazeneca Upstream E. coli K12 Process Optimisation 12 batches Feed-forward NN Chemotaxis algorithmInput/Control Parameter; Process Variables Biomass small data; model complexity; nonlinearity Neural networks are capable of capturing the nonlinear relationship between the fermentation input and output variables with limited a priori knowledge about the process structure (continued on next page) DigitalChemicalEngineering7(2023)100080 14 T.D.Pham et al. Table C.3 (continued).

On-line Monitoring:

Article Title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development
Article Snippet: Melcher et al. (2015)To apply 2 ML models to predict endpoint measures from spectroscopy online data Austria N/A Upstream E. coli Predictive Modelling 25 cultures RF; Feed-forward NN; PLSR N/A Process Variables; Mass Spec / Chromatography Cell dry mass; Product concentration missing data; multi-collinearity; time series Using neural networks as a modelling technique and random forest as a variable selection tools gives satisfactory prediction accuracy from process variables and spectroscopic data Glassey et al. (1994) To use feedforward ANN to predict biomass concentration from feed rate, batch age, batch concentration, feed initiation time, and fermentation temperature United Kingdom Astrazeneca Upstream E. coli K12 Process Optimisation 12 batches Feed-forward NN Chemotaxis algorithmInput/Control Parameter; Process Variables Biomass small data; model complexity; nonlinearity Neural networks are capable of capturing the nonlinear relationship between the fermentation input and output variables with limited a priori knowledge about the process structure (continued on next page) DigitalChemicalEngineering7(2023)100080 14 T.D.Pham et al. Table C.3 (continued).



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